Cannabinoids are types of compounds that are naturally found in the marijuana plant (cannabis sativa). Cannabidiol (CBD) is the main compound here and it has been proved that it has anti inflammatory effects when put into animal cells. Tetrahydrocannabinol (THC) is another one of these compounds and it is said to give off a psychotropic effect. Cannabinoid receptors (CB1 and CB2) are found in the endocannabinoid system and allow cannabinoids to bind and work in the body. This paper will cover the last 5 years of anti-inflammatory properties of all types of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol, synthetic analogs, such as ajulemic acid and nabilone, in anti inflammation.
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Cannabinoids may reduce inflammation
It is said to be an update on the issue of the involvement of cannabinoids in the activities of inflammation. A possible mechanism for these activities is suggesting that an increased production pattern of good cell growth will promote the resolution of inflammation. This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that decrease the synthesis of normal cell growth that promote the induction of the inflammatory process.
Cannabinoids could potentially be used to treat chronic pain
Possibly the very earliest paper reference on Cannabis describes its ability as an anti-inflammatory drug. The Chinese emperor Shen-nung (ca. 2000 B.C.), in a paper called Pen-ts’ao Ching, suggested many of the effects of Cannabis in humans. Among other actions, it was said that cannabis undoes rheumatism. This means that it has possible effect on decreasing inflammation. The reports in this review of the current literature give support for the claims made by the ancient Chinese healers. More recently, papers include relief from chronic neuropathic pain, fibromyalgia, rheumatoid arthritis, and postoperative pain. In addition, a large body of preclinical data on all classes of cannabinoids, including the endogenous examples, point to a variety of therapeutic targets for cannabinoids and important roles for the endocannabinoids in the physiology of inflammation.