Cannabinoid System And Its Role In The Treatment Of Mental Diseases | cannabisMD

Cannabinoid System And Its Role In The Treatment Of Mental Diseases

Cannabinoid System and its Role in the Treatment of Mental Diseases; Springer

Springer

Role Of The Endocannabinoid System In Mental Diseases

Cannabinoids are found in the marijuana plant (cannabis sativa) and are said to be effective in pain management from pain symptoms such as multiple sclerosis, diabetic neuropathy, peripheral neuropathy and nausea and vomiting. A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that mediates neurotransmitter release in the brain.

Cannabinoids for these receptors include the endocannabinoid system , that are produced in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non-psychotic effect. This paper looks at how cannabinoids can help people with mental health issues.

Cannabis May Be Used To Treat Chronic Pain

In the past few years, a large number of studies applying THC, the prime active factor derivative of the cannabis plant, or cannabinoid synthetic derivatives have massively contributed to developing the understanding of the pharmacology and neurobiological actions made by cannabinoid receptor triggering. Cannabis has been used to provide solace with some of the signs related to central nervous system syndromes. These days, there is anecdotal proof for the appliance of marijuana in many people dealing with multiple sclerosis or chronic pain.

Following past results on the use of cannabis for medicinal reasons, recent studies have pointed at the potential of cannabinoids to heal a wide range of clinical syndromes. Some of these syndromes that are being looked at are pain, motor dysfunctions, or psychiatric illness. On the other hand, marijuana addiction has been associated with several psychiatric syndromes such as:

  1. Dependence
  2. Anxiety
  3. Depression
  4. Cognitive impairment
  5. Pychosis

Considering that marijuana or cannabinoid pharmaceutical agents may no longer be exclusively recreational substances but may also hold potential therapeutic applications, it has become of great intrigue to review the neurobiological and behavioural impacts of their appliance. This study tries to build a bridge between knowing the basic neurobiology of the endocannabinoid system to novel chances for therapeutic interference and its impacts on the central nervous system.

The considerable development in the pharmacological and physiological actions of THC or cannabinoid synthetic derivatives (agonists and antagonists) has led to the discovery of an endogenous cannabinoid system in the central nervous system. The neuromodulatory job of this new neuronal system massively indicates that direct or indirect modulations of this cannabinoid system using receptor agonists, antagonists or specific inducers of reuptake systems of the endogenous cannabinoids might be possibly applicable in the healing of a wide range of neuropsychiatric syndromes.

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