Cannabinoid Pathways: Neuroinflammatory Disease | cannabisMD

Cannabinoid Pathways and Neuroinflammatory Disease

Neuroinflammation disease and cannabiniods

This study looks at cannabinoids as a treatment for a wide range of neuroinflammatory diseases. Many studies have found that they can treat a variety of ailments. Especially inflammatory diseases such as arthritis and multiple sclerosis. Cannabinoids are found in the marijuana plant and they contain therapeutic abilities. Cannabinoids are fortified with extracts of tetrahydrocannabinol (THC) and cannabinol (CBD). THC is the psychoactive and CBD is non psychoactive. This paper will look at how cannabinoids can actually have a positive effect on neuroinflammatory diseases.

Here is the full scientific article if you wish to download it.

Cannabinoids Have Potential to be Antiinflammatory Agents

The idea of the central nervous system as an immune-privileged target appears to be overly simplistic. This is mainly because of the existence of the blood brain boundary. Within a healthy central nervous system (CNS) immune actions are allowed. These are needed for brain function and host defense. Long-term and continuing neuroinflammatory reactions are important and describe numerous neuroinflammatory disorders. These disorders include but are not limited to:

  • Multiple sclerosis
  • Alzheimer’s disorder
  • Amyotrophic lateral sclerosis

A developing sustenance of reports indicate that cannabinoids are held up with massive immunomodulatory and anti-inflammatory abilities. These are both seen in peripheral cells and in the central nervous system. This is performed through the triggering of cannabinoid receptors.

What does the paper discuss?

  • The immunoregulatory impacts of cannabinoid transmissioning on the most important brain immune cells are discussed throughout the paper.
  • The effect of cannabinoid modulation on the overall integration of the manifold brain immune reactions is also discussed.
  • Problems relating to these chemicals as plausible drugs for the mediation of neuroinflammatory diseases is another topic covered in this study.

There’s a great cache of data depicting cannabinoid-based and cannabinoid 1 and 2 receptor–targeting agents. Theses are seen as potential mechanisms in the curing of neurodegenerative disorders and neuroinflammatory syndromes. Intriguing new discoveries unravelled a potential unexpected fault of cannabinoids and cannabimimetic chemicals. Chronic exposure to marijuana has been displayed to cause:

  1. Microglial triggering
  2. Subsequent cerebellar degeneration through mediated expulsion of glutamate by cerebellar brain cells.

Such impacts open the plausibility that, at least under specific circumstances, plant cannabinoids could lead to neuroinflammation instead of neuro security.

The impacts of these chemicals are quite complicated. The result of their mechanisms on the immunopathological side of neuro degradation and neuroinflammation can rely on:

  1. Their forward mechanism on the cellular parts of inflammation
  2. on secondary happenings, in a quite complex way

Further treatments will have to look at both sides of the coin, as well as the potential of more adverse events of cannabinoid-associated agents. All of which involve volume decreasing of crucial memory-related brain regions and the beginning of psychopathological problems.

Jonathan Neilly
Jonathan Neilly
Jonathan Neilly is registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in his life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

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