Cannabidiold’s neuroprotective effect gave a bell-shaped curve implying that the effects relied on the dose. An increased amount of abnormal cannabidiol failed to decrease the infarct volume while a same sort of curve resulted from a cannabidiol analog, the abnormal cannabidiol. Cannabinoids bell-shaped pattern did not come as a shock since a somewhat same curve was witnessed in relation to the anti-inflammatory effects of CBD in a murine collagen-induced arthritis model.
In addition to this, by making use of an intracerebroventricular self-administration paradigm in rats, it is believed to provide the properties of CP55, 940. A similar bell-shaped curve dependent on dose was experienced for the electroencephalographic flattening of total power in gerbils based on cerebral ischemia. This occurred because of the cannabidiol.
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While the most recent studies show that cannabidiol can produce a complete, yet not a very strong biological response in humans VR1,12, the neuroprotective effects brought about by cannabidiol might not be similar because of a VR1 antagonist, capsazepine. Hence, the finding that the bell-shaped curve produced by cerebral infarction with higher quantities is linked to VR1 is somewhat proven wrong. Moving on to the next reason, it is observed that since groups on phenol hydroxyl (Structure of Resorcin) in CBD play a part in the production of carbon monoxide, it is believed that cannabidiol is responsible for producing carbon monoxide.
In addition to this, ischemic stroke mortality and carbon monoxide are considered to be highly linked. The reports conclude that at increased doses because of MCA occlusion, huge infarction might be produced by cannabidiol. This is made possible by enhancing carbon monoxide production. Similarly, with relatively less dosage, infarct volume encouraged by the rigorous situation (i.e., a 4-hour MCA occlusion), might not be prevented by cannabidiol.
This study, in reality, showed that lower or higher quantities of cannabidiol triggered the 4-hour MCA occlusion to inflate infarct volume. There is a need to observe the dosage response curve of CBD properly.