Cannabidiol - Potential Treatment for Anxiety | cannabisMD

Cannabidiol as a Potential Treatment for Anxiety Disorders

Potential treatment of cannabidiol for anxiety disorders

Cannabidiol, a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD’s potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies.

Here is the full scientific article if you wish to download it.

We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing.

Evidence from human studies supports an anxiolytic role of CBD but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with a need for further study of chronic and therapeutic effects in relevant clinical populations.

Preclinical studies on Cannabidiol for Anxiety

The preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple neurological disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects. While it can improve mental health, it can also help physical health.

CBD’s anxiolytic actions appear to depend upon CB1Rs and 5-HT1ARs in several brain regions; however, investigation of additional receptor actions may reveal further mechanisms. Human experimental findings support preclinical findings, and also suggest a lack of anxiogenic effects, minimal sedative effects, and an excellent safety profile.

Current preclinical and human findings mostly involve acute CBD dosing in healthy subjects, so further studies are required to establish whether chronic dosing of CBD has similar effects in relevant clinical populations. Overall, this review emphasizes the potential value and need for further study of CBD in the treatment of anxiety disorders.

Jonathan Neilly
Jonathan Neilly
Jonathan Neilly is registered with the British Psychological Society, breaking the taboo on mental health issues is one of the driving forces in his life. His background in biomedicine gives him additional understanding of the factors that work together to influence the human condition.

Leave a Reply

Your email address will not be published. Required fields are marked *