Cannabidiol is more commonly known as CBD or CBD oil. It is oil that extratced fromt he cannabis plant, but dosen’t contain any of the psychoactive effects associated with smoking cannabis. After suffering from hypoxia-ischemia (HI), when an immature brain is treated with the use of cannabis, this results in neuroprotective effects, even if they are of the short-term. The next step was to see if these effects lasted in the longer run. Wistar rats were used for this purpose, which were inflicted with HI injury by electrocoagulation of the left carotid artery, after which they were exposed only to 10% oxygen for 120 minutes.
After all this, these rats were given either 1 mg/kg CBD (HC, n ¼ 23) or vehicle (HV, n ¼ 22). Sham animals underwent the same treatment (SC, n ¼ 16 and SV, n ¼ 16). Histological evaluation, Western blotting, magnetic resonance spectroscopy and magnetic resonance imaging were used to determine the full extent of brain damage.
After 30 days of HI, novel object recognition and many neurobehavioral tests (RotaRod, cylinder rear test) were conducted.Results of all neurobehavioral tests at P37 showed enduring functional impairment because of HI. Results for both sham animals and HC animals were similar (all p 0.05 vs HV).Within 7 days of HI, CBDs were used to influence inflammation, oxidative stress and brain excitotoxicity. Use of these resulted in a reduction of the extent of histological damage anda 17% (p 0.05) decrease in brain infarct volume.
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There was no difference to be seen between SC and SV groups in all experiments.This leads to the conclusion that when newborn rats suffer from HI injury and are treated with CBDs, this results in ever-lasting neuroprotection, with more emphasis on promotion of functional instead of histological recovery. All aforementioned CBD effects carried no side effects, and resultantly further accentuated interest in CBD as a neuroprotective agent for HI.