Is the cardiovascular system a therapeutic target for cannabidiol?
Cannabidiol (CBD) is derived from the cannabis plant. Cannabinoid is one of the main constituents in Cannabidiol and its first medical use was described in 1963. Acute administration of CBD has been found to have numerous benefits in the cardiovascular system. It is mainly beneficial as it has direct effect on single arteries leading to anti inflammation. Additionally, it prevents damage of the liver and brain, and it positively affects blood cell function that delays cardiovascular disease.
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Different studies on the advanced vascular effects of cannabinoid, endocannabinoids, and phytocannabinoids have been found to lead to relaxation of the heart, this reducing the risk of heart disease. However, only a few medical studies have established the the actual response to cannabinoid in the cardiovascular system. Some studies have shown that it affects the arterial blood pressure without affecting heart rate. Additionally, cannabinoid treatment did not affect animal heart rate or blood pressure. On the other hand, it would be important to study the likely hyperintensive effects on animals or people with high blood pressure.
Apart from improving vasorelaxation, cannabinoid also helps prevent damage of the brain and the liver. Vivo treatment using cannabinoid reduces heart sizes by improving its health. In their study, 11 weeks of using cannabinoid had significant effects on diabetic mice such as lower cardiac dysfunction, less myocardical inflammation, fibrosis, nitrative stress, and oxidative stress. Consequently, cannabinoid in vivo treatment has considerable cardio protective effects that can be attributed to the anti-inflammatory mechanism.
Evidently, CBD products have positive effects on circulation in the heart, and it does not stop at that because it also affects blood cell function. In the blood cells, cannabinoid increases
lipooxygenase, and phospholipase products in the body’s platelets. It also prevents cell death through anti-oxidant mechanisms. Therefore, cannabinoid has a positive influence in the death and survival of white blood cells, which enhances the prevention or delay of cardiovascular problems.
The study shows that cannabinoid has positive effects on cardiovascular system, thus reducing the risk of heart attack. However, in future it would be important to carry out a study based on various sites as these are yet to be established. Additionally, the study was done on mice and it is yet to be established whether it will have similar effects on a human cardiovascular system.