In this study, CBD offered short term neuroprotection in immature brains following hypoxia-ischemia (HI). HI occurs in infant’s brains when they do not receive enough oxygen and blood. Newborn Wistar Rats underwent HI injury within this study.
They were given 10% oxygen for 120 minutes after left carotid artery electrocoagulation. Endovascular electrocoagulation involves using radio frequency (RF) for blockage or closing of a blood vessel. This would cause the lack of proper blood and oxygen circulation. They then were a vehicle (HV, n=22) or 1 mg/kg of CBD (HC, n=23).
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Sham animals had similar treatments. Sham animals undergo the same operative procedures, without the therapeutic benefits. They were treated with SV, n=16 and SC, n=16 instead.
The purpose of the study was to determine if CBD neuroprotection can be sustained over a prolonged period of time. The neuroprotective action of CBD was associated with the modulation of excitotoxicity, oxidative stress, and inflammation, over a span of 7 days.
CBD was not associated with adverse side effects. These results indicate that CBD has potential as a neuroprotective treatment and a useful partner for other neuroprotective strategies.
Several tests were carried out 30 days after H.I. CBD reduced brain infarct volume by 17%. It also lessened the extent of histological damage. Infarct volume is for assessing the extent of ischemic brain injury. Histological damage access the level of damage to cells and tissues in animals and plants using microscopy.
The extent of brain damage was assessed through:
In this study, the researchers examine newborn rats who experienced severe neurological trauma. They administered CBD to a test group. The results demonstrated that the rats who had received CBD administration experienced long-lasting neuroprotective effects. In contrast to results reported with other neuroprotective treatments, CBD was more effective in recovering functional parameters than restoring histological markers.