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Marijuana comes from the C.Sativa plant and is smoked by 4.5% of the world’s population. Cannabinoids are found in this cannabis plant and it both holds the chemicals tetrahydrocannabinol (THC), which is psychoactive, and Cannabidiol (CBD), which is anti psychotic. CBD is said to reduce anxiety and have anti inflammatory properties. Previous studies have shown that THC and CBD can wake you up from a normal sleep cycle. In this study, evidence will be given on the potential role of CBD as a wake-inducing drug.
It has been seen in previous studies that CBD has been shown to have a wake inducing effect, however this study showed a contradictory report. This may be because of differences in each studies method. Further experiments will need to be carried out so that the potential mechanism of action of CBD on sleep modulation can be realised.
Sleep disturbances such as dyssomnia, parasomnia, and from medical disorders have the potential to be treated with CBD oil. Data from the national sleep foundation has showed that 36% of its subjects have fallen asleep while driving. When CBD is administered, c-Fos expression is achieved in the hypothalamus part of the brain, which promotes alertness. CBD administration enhances c-Fos expression in the dorsal raphe nuclei (DRN) which also promotes alertness. It is known that electrophysiological activity of DRN is higher in the waking state and decreases during sleep, being virtually absent in REM sleep.
Several pieces of evidence have shown that CBD acts as a positive compound in different treatments to manage several health conditions, such as psychiatric and neurodegenerative disorders. This means that medical cannabis could possibly be used as a mechanism for sleep modulation, however more studies will need to be carried out to determine if it can be used as an effective wake-promoting agent.CN-12-269