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Cannabinoids are a group of chemicals from the plant cannabis that work in the body through cannabinoid receptors. Tetrahydrocannabinol (THC) is the main psychoactive part of marijuana, as well as the discovery of cannabinoid receptors has caused a massive growth in studies looking at the physiological functions of cannabinoids. Cannabinoid receptor 1 mostly works in the brain and cannabinoid receptor 2 is found in the cells in the immune system. This means that these receptors have a part to play in the regulation of the immune system. This paper will look at how cannabinoids can be used to make anti inflammatory drugs to fight autoimmune diseases that are triggered by activated T cells or other cellular immune constituents.
Here is the full scientific article if you wish to download it.
Cannabinoids have anti inflammatory effects
New research has shown that THC induced in mice can cause death in T cells and dendritic cells, concluding in immunosuppression. Adding to that, more studies have shown that cannabinoids can help with the regulation of cytokine and chemokine cells produced and hence fight inflammation. Immunoregulation is controlled by the endocannabinoid system. By controlling these endocannabinoids, or use of cannabinoids, can lead to a potential treatment for inflammatory diseases.
Cannabinoids have immunoregulation properties
The cannabinoid system has been demonstrated to regulate the immune system through its immunomodulatory properties. Cannabinoids can suppress inflammatory immune responses and therefore reduce disease symptoms. This ability of cannabinoids is produced through multiple pathways like the induction of cell death in activated immune cells, decreasing of cytokines and chemokines in inflammatory cells and the regulation of FoxP3+ regulatory T cells. Cannabinoids have been seen to treat autoimmune disorders such as rheumatoid arthritis multiple sclerosis and hepatitis and have been demonstrated to heal the host of multiple anti-inflammatory pathways. Cannabinoids can be then made into drugs for effective treatments in acute inflammation in the central nervous system because they have anti inflammatory properties with little psychoactive effects and no other side effects.