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Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
A cannabinoid is one of a collection of complex chemical compounds that operates on cannabinoid receptors in cells that fluxuates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoids, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will look at how cannabinoids can have anti tumoral properties and how this may lead to to a treatment for hepatocellular carcinoma, a form of liver cancer.
Therapeutic potential of cannabinoids
Hepatocellular carcinoma (HCC) is the third cause of cancer-related death around the world. When these tumors are in advanced stages, few therapeutic options are available. Therefore, it is detrimental to search for new therapeutics to fight this disease. Researchers in this study dissected the effects of cannabinoids – a novel family of possible anticancer drugs – on the development of HCC. It was discovered that THC the major constituent of cannabis sativa and a specific cannabinoid receptor agonist decreased the viability of the human HCC cell lines, an impact that depended on the triggering of CB2 receptor. Studies demystified that THC and the specific cannabinoid receptor agonist decreased the development of HCC subcutaneous xenografts, an impact did not show when cell death was genetically of pharmacologically induced in those tumors. Moreover, cannabinoids were also able to induce tumor development. These results may hand to the structure of new therapeutic plans for the management of HCC.
Cannabinoids tumerol strategies
This research displays that the actions of cannabinoid anti-tumoral mechanisms in HCC depends on the triggering of cell death and the following triggering of cell death. Depending on the physiopathological situation, cell death has been put forward to save from apoptosis, and act as a different cell death pathway. However, not much is known about the job that the relationship of these two cellular methods that have in the mediation of tumor development in response to anticancer drugs. These results are in line with old conclusions received in human glioma cells and support the fact that triggering of autophagy in reaction to cannabinoid treatment leads to cell death. Nevertheless, more research is still required to shed light on the precise mechanisms linking both cellular mechanisms upon cannabinoid treatment.