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Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
A cannabinoid is one of a great collection of complex chemical compounds that naturally occur in the body and operates on major cannabinoid receptors in cells that fluxuates neurotransmitter release in the brain. Cannabinoids for these receptors include the endocannabinoid system, that are made naturally in the body by animals, the phytocannabinoids in cannabis and some other plants, and synthetic cannabinoids. The main cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC), the primary psychoactive chemical in cannabis. Cannabidiol (CBD) is another main constituent of the plant and produces a non psychotic effect. This paper will review the literature on experiments that focused on finding out endogenous cannabinoids antitumor effects in malignant gliomas.
Cannabinoids are promising compounds for the treatment of gliomas
To review, through a systematic evaluation of the literature, the anti tumor impacts of cannabinoids on glioma cells. All published research involving the antitumoral impacts (cellular and molecular mechanisms) of cannabinoids were taken into account for this report. In all experimental studies involved, cannabinoids put force on antitumoral actions in numerous models of tumor cells and tumors. The antitumor activity included: antiproliferative impacts, reduced viability and cancer cell death by toxicity, apoptosis, necrosis, autophagy, as well as antiangiogenic and antimigratory impacts. Antitumoral evidence included: decrease in tumor size, antiangiogenic, and antimetastatic impacts. Additionally, most of the research described that the cannabinoids showed specific antitumoral action in numerous distinct tumor models. Thereby, normal cells used as controls were not impacted. The safety factor in the cannabinoids’ administration has also been displayed in this study. The different cannabinoids used in multiple tumor experiments showed anti inflammatory impacts. These results suggest that cannabinoids are potentially viable for the treatment of gliomas.
Cannabinoids can induce malignant cell death
Overall, the concomitant use of ceramide and cannabinoids may be an intriguing plan in some groups of tumors so effectiveness is increased and the adverse events are minimized. This relationship with ceramide is already being taken out in some treatment methods together with normal chemotherapies. These ones, in turn, grouped with cannabinoids, could bring intriguing antitumoral impacts, as seen in two recent studies. In this sense, this report displays that cannabinoids can be considered an amazing treatment potential, specifically on account of the current rarity of efficient resources to treat some cancer conditions in medicine.Systematic-review-of-the-literature-on-clinical-and-experimental-trials-on-the-antitumor-effects-of-cannabinoids-in-gliomas