Cannabinoids are a group of chemicals derived from the cannabis plant (cannabis sativa). Cannabidiol (CBD) is one of these chemicals and research has shown that it has anti inflammatory properties to heal animals with nervous system disorders. Tetrahydrocannabinol (THC) is another one of these compounds that wields a psychoactive effect in animals. Cannabinoid receptors (CB1 and CB2) are found in the endogenous cannabinoid system and allow cannabinoids to bind and do their job in the body. This paper will look at how cannabinoids can be used as anti inflammatory agents to treat a whole range of human disorders.
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Cannabinoids can be used to treat Arthritis
The identification of substances that can promote the resolution of inflammation in a way that is homeostatic, modulatory, efficient, and well-tolerated by the body is of fundamental importance. Traditional medicines have long provided front-line pharmacotherapy for many millions of people worldwide. Cannabis extracts are a rich source of therapeutic leads for the pharmaceutical industry. The use of medicinal plant therapies to treat chronic illness, including rheumatoid arthritis (RA), is thus widespread and on the rise. The aim of this paper is to present recent progress in clinical anti-inflammatory studies of plant extracts and compound leads such as green tea polyphenols, curcumin, resveratrol, boswellic acid, and cucurbitacins, among others, against chronic inflammatory diseases, mainly RA. In this context, the present study also highlights the potential, based on experimental data, of those plant extracts and pure chemicals active in animal models of the aforementioned diseases.
Cannabinoids can be used to treat Inflammatory Bowel Disease(IBD)
Traditional medicine and natural products are a rich source of leads for the advancement of therapeutics for chronic diseases such as RA or IBD. However, the path from traditional medicines/natural products to Western pharmaceutical practices is not always easy. The variability of responses of phytomedical practices can be explained in terms of the usually strong dependence of plant secondary metabolite profiles on environmental signals that can affect reproducibility of results with extracts. This would be reduced if the principles of standardization of extracts and enriched fractions were exhaustively applied. Another important limitation with natural products is insufficient amounts, required for development and clinical use. This paper summarized the therapeutic effectiveness of some natural products employed as anti inflammatory drugs against RA and IBD. All these results strengthen the fact that natural products can modulate various molecular pathways involved in inflammation. Accumulating evidence suggest that cannabis might potentially be the best candidate of a new type of anti-inflammatory drugs. And while the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for natural CBD products as pharmacological interventions against chronic inflammatory diseases.