CBD Oil Side Effects: All Of The Facts with None of The Fiction | cannabisMD

CBD Oil Side Effects: All Of The Facts with None of The Fiction

cbd oil side effects facts fiction

Cannabidiol has few side effects and is considered generally safe. The safety of cannabidiol was tested through many clinical trials for a range of ailments.

Studies have shown these are the primary side effects of CBD:

  1. Inhibition of hepatic drug metabolism/decreased activities of p-glycoprotein and other drug transporters
  2. Dry mouth
  3. Increased tremor in some Parkinson’s patients
  4. Low blood pressure
  5. Lightheadedness
  6. Drowsiness

Cannabidiol Basics

Cannabidiol (CBD) is the second best known cannabinoid in the cannabis plant, just after the psychoactive part of the cannabis plant tetrahydrocannabinol (THC). Though the compounds, CBD and THC, share the same origin, they do not have the same traits or effects. They play very different rolls in regard to the human body.

THC is about to make people high through binding to the CB1 receptor in the brain. It provides a range of health benefits because of its analgesic, anti-inflammatory and neuroprotective properties. The side effects, for some, outweigh the benefits. As such, THC is not always a suitable treatment solution for many applicants, with CBD as a non-psychoactive alternative.

Unlike THC, CBD has a stronger affinity for the CB2 receptor. It interacts differently with the nervous system and does not elicit any psychoactive effects. CBD has numerous health benefits, such as antioxidant, antiemetic, anticonvulsant and anti-tumoral properties. CBD acts as a natural antidepressant and neuroprotective agent

There are more and more novel studies demonstrating the overall efficacy of cannabidiol in treating a range of medical conditions. Most of these studies conclude CBD is safe and virtually free of side effects.

This NCBI paper on the safety and side effects of cannabidiol suggests that controlled cannabidiol administration is safe and non-toxic in humans and animals. It does not change foot intake, nor affect biological functions like heart rate, body temperature or blood pressure. According to this review paper, “high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.” There are very few known side effects compared to conventional medications.

Inhibition of Hepatic Drug Metabolism:

CBD can interact with a series of pharmaceutical medications, as it lessens the activity of some liver enzymes called cytochrome P450. This enzyme is used to metabolize many of the conventional pharmaceutical drugs used to treat health conditions in humans. If a patient takes too high of a dose of CBD, the cannabinoid can temporarily neutralize the activity of these enzymes and, as such, change the way the drugs are metabolized.

However, to put this in a wider perspective, eating a piece of grapefruit would have a similar effect on P450 enzymes. This is a minor, temporary side effect but if you are prescribed pharmaceutical drugs and wish to take CBD, we suggest you discuss your choice with your doctor or a health professional.

Dry Mouth:

Another commonly reported CBD side effect is dry mouth. This seems to be due to the endocannabinoid system’s ability to inhibit saliva secretion. In 2006, Argentinian researchers, in a study, published that cannabinoid receptors (CB1 and CB2) are in submandibular glands which are responsible for the production of saliva. This is to say, when these receptors are activated, they alter salivary production causing dry mouth. This symptom is fairly minor in most cases and can be addressed with quenching your thirst.

Increased Tremor in Parkinson’s Disease at High Dose CBD:

Early research showed that CBD, if taken at high doses, can worsen tremor and muscle movement in patients who suffer from Parkinson’s. There were opposing studies, however, that suggested cannabidiol is safe and well-tolerated by patients with Parkinson’s disease. If this happens, the quickest solution is reducing the dose to a more tolerable level. Sufferers of Parkinson’s disease should always consult their doctor before taking CBD and also begin new regimen with smaller doses.

Low Blood Pressure and Lightheadedness:

Higher doses of CBD oil may cause a small drop in blood pressure, usually within the first few minutes of CBD entering your bloodstream. This drop in blood pressure is associated with feeling lightheaded. If you are on medication for blood pressure, consult your doctor before taking CBD. This side effect of CBD is temporary and will go away with a cup of coffee or tea.


CBD can cause drowsiness in higher doses. If you are specifically susceptible to this side effect, you should avoid operating heavy machinery or driving a vehicle while using CBD. In a majority of cases, individuals respond opposingly, making CBD a wake-inducing agent.

Medical marijuana and CBD products are becoming exceedingly acceptable in the mainstream. Clinical trials are starting to fill the scientific knowledge gaps around the needlessly-taboo cannabis plant. As the safety and side effects of cannabidiol and tetrahydrocannabinol show to be more than acceptable, patients with conditions like chronic pain, anxiety disorders, HIV, etc. have hope of a less-dangerous, lower side effect medical solution to their ailments.

This is to suggest CBD has potential in the medical and health industry just beginning to be discovered. The full marvels that CBD has to offer are still being discovered. In the meantime, if you want a low side effect medical solution to a range of minor to serious ailments, you may just want to buy CBD and try it out yourself. This is solely if CBD products are legal where you live, and CBD does not poorly interact with your current medical regimen. THC and CBD have different laws and CBD is non-psychoactive. Be sure to check your laws if unsure.

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