Cannabinol as a Potential Anti-Cancer Agent? | cannabisMD

Cannabinol as a Potential Anti-Cancer Agent?

Cannabinol as an Anti-Cancer Agent

Cannabinoids are considered to be therapeutic in the treatment of chronic pain via their neuroprotective and anti inflammatory functions. They are also said to have anti cancer mechanisms through their anti inflammatory profile. Cannabinoids can occur naturally within plants, humans and animals. The most famous cannabinoids from the cannabis plant are CBD (Cannabidiol) and THC (Tetrahydrocannabinol).

CBD is the cannabinoid which has been found to have many anti-inflammatory properties and THC is widely known to get people high. Although it is being researched for its potential neurological
benefits. The cannabinoids in question are believed to stimulate and in some cases bind with CB (Cannabinoid) receptors in our endocannabinoid system (ECS), which in turn can increase or decrease in a regulatory fashion, how our bodies react to certain external influences.

For example if we get an infection our ECS could send out too many defenses to target it and as a result cause an overreaction with negative side effects such as the itching and burning from acne. Acne would be considered a minor in relation to cancer, the topic in which our attached paper discusses. Here it will detail how CBD can be used for treating cancer.

CBD Does Not Have Psychoactive Effects

Both normal and lab grown cannabinoids have been seen to prevent the development of tumor cells in the lab and in animal designed experiments by impacting key transmissioning routes including angiogenesis, a massive step in tumor development, invasion, and metastasis. In this research, scientists looked for cannabinoid-like anticancer drugs not wielding the psychoactive adverse events, and went on to synthesize and review the anti-angiogenic impacts of a novel types of cannabinol networks.

Among these, two cannabinoids were picked based on their anti-angiogenic ability and lack of attaching effectiveness for cannabinoid receptors. Both LYR-7 and LYR-8 cannabinoid types induced VEGF-induced proliferation, migration, and capillary-like tube manufacturing of HUVECs in a dose-reliant mechanism.

CBD May Have the Ability to Halt Cancer Growth

The inducing impact of the chemicals on cell development was more specific in endothelial cells than in breast cancer cell tissues. Researchers here reported efficient inducing of VEGF-inhibited new blood vessel production by the chemicals in the chorioallantoic membrane (CAM) solution. More so, both LYR systems strongly induced VEGF manufacturing and NF-κB transcriptional functions in cancer cell tissues.

More so, LYR-7 or LYR-8 strongly repressed breast cancer cell-persuaded angiogenesis and tumor development. Overall, these conslusions indicate that normal synthetic hexahydrocannabinol networks, LYR-7 and LYR-8, stop tumor development by citing VEGF-mediated angiogenesis transmissioning in endothelial cells and preventing VEGF manufacturing and cancer cell development.

Cannabinol Potential Anti-Cancer Agent

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